Phentermine 37.5 (Adipex)

Managing obesity is a battle that looks different for every patient. It can be a tricky health concern that requires a customized approach, and there’s a long list of treatment solutions available. The intended use of Phentermine is for the short-term therapy of obesity.

There’s a natural element to Phentermine that makes it a viable solution for many people, but it’s much more intricate than you might think. Phentermine has been in clinical use for over fifty years, and it’s still regarded as an excellent tool when it comes to managing obesity.

As you read through this article, you’ll learn about the specific details of how Phentermine works and the fine print regarding its efficacy.

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Medication: Phentermine (Generic Adipex)
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Breaking Down Phentermine

The drug is a natural monoamine alkaloid derivative. Phentermine (Adipex) is also a stimulant that comes with an appetite suppressant property. It’s able to stimulate the hypothalamic release of norepinephrine. This is a neurotransmitter that’s directly correlated to stress responses in the body, and it also reduces sensations that come from hunger.

Phentermine has the ability to break down stored fat as it causes the release of epinephrine and adrenaline outside of the brain. Overall, Phentermine is able to help suppress appetite and signals associated with hunger. In turn, this can make it much easier for patients to manage obesity. The drug can be used in conjunction with other treatments for obesity to achieve the desired outcome.

Phentermine can inhibit the reuptake of noradrenaline, serotonin, and dopamine. This is made possible through the process of inhibition or reversal of the reuptake transporters. The drug is also known to leave more neurotransmitters available at the synapse by inhibiting MAO enzymes.

There are many specific details related to Phentermine that shouldn’t be overlooked regarding the treatment of obesity. Although the drug is widely used for these circumstances, it may not be an optimal choice for every patient. First, let’s take a look at how administration of the drug works.

Using Phentermine

Whether it’s tablets or extended-release capsules, Phentermine is easily digestible for most people. In most cases, the drug is taken once daily in the morning or three times a day before each primary meal.

The prescription will come with specific instructions on the label, and these instructions may vary from patient to patient. Doctors will work with patients on the length of the treatment, and this pertains to the patient’s response to the medication.

It can be a habit-forming drug, so Phentermine is generally carefully administered. The drug shouldn’t be taken outside of the prescribed intake schedule, and extended-release capsules should be taken whole. This isn’t a drug that can be split, crushed, or chewed.

Phentermine could possibly affect leptin levels in the brain indirectly. It can also inhibit neuropeptide Y, and this peptide initiates the signal for eating and increases storage for fat. Aside from how it should be used, the pharmacodynamics of the drug provides much more insight into how it operates within the body.

Taking a look at the mechanism of action

There are many studies available that highlight different points regarding the efficacy and mechanism of action for Phentermine. Data suggests that the drug increases resting energy expenditure. In turn, this has the potential to lead to noticeable weight loss. Studies also show that Phentermine works better than many traditional medical weight loss methods.

After treatment comes to an end, Phentermine has shown that it can help with the overall maintenance of the weight loss process. It should also be noted that Phentermine does not elevate blood pressure or produce the central nervous system stimulation effects related to amphetamines.

When directed by a doctor, the drug is seen as a safe solution with minimal side effects. However, side effects can vary from mild to more severe and can become more prevalent if the intake schedule isn’t followed with care.

Considering that Phentermine can be habit-forming, the drug should not be taken any longer than the prescription directs. Individuals who have a known history of uncontrolled high blood pressure or heart disease should steer clear of Phentermine. The drug should be utilized in conjunction with a detailed weight loss plan along with regular diet and exercise.

Research is still currently underway regarding the numerous use cases and efficacy of Phentermine. Although the drug is actively in use for many people, scientists agree there’s still a lot to learn about the treatment. This also means that potential side effects and health concerns are also being explored.

Known health risks

At this time, there are a minor potential health risks that doctors are well aware of regarding the administration of Phentermine. Some are more common than others, but a few patients have reported more severe side effects. There’s always the potential that this comes down to user error, but in some circumstances, it’s simply a matter of one’s health condition.

A few common side effects of Phentermine (Adipex) include:

  • Dry mouth
  • Constipation
  • Vomiting
  • Diarrhea
  • Unpleasant taste

Clearly, many of these are quite manageable and may not pose much of a threat to a patient’s health. However, in extreme cases, side effects can become much worse. This is especially true if the side effects are left unchecked, and each patient should notify their doctor if they experience them at all.

More severe side effects include the following:

  • Shortness of breath
  • Increased blood pressure
  • Restlessness
  • Chest pain
  • Dizziness
  • Difficulty exercising
  • And more

Some of the side effects associated with Phentermine can seem quite daunting, but they’re definitely not a guarantee. The health risks associated with Phentermine are listed solely because their presence has been recorded at some point in history. Some of them are extremely uncommon and can be managed with the help of a healthcare professional.

Any time you’re looking at taking a drug you’re not used to, it’s bound to generate quite a few questions. If you keep reading below, you’ll find a comprehensive FAQ that covers questions that are common among most patients.


Does Phentermine work for everyone?

Your doctor may explore Phentermine as an extra step in your weight loss journey, but there’s no guarantee that they’ll move forward with this decision. Based on certain health factors, some people may not be considered a good candidate for the use of Phentermine.

In other cases, Phentermine may be used in the short or long term in rare circumstances until the desired results are met for managing one’s obesity. Each patient’s experience with managing obesity will be a unique one, and it can be easier or much more difficult, depending on the status of their health.

Can the elderly take Phentermine?

Unfortunately, Phentermine isn’t an option for those who are 65 and older. The risks are heightened for older patients, and there are similar medications on the market that are much safer.

Of course, a doctor will look at this on a case-by-case basis and thoroughly determine if a patient’s health can handle Phentermine. You can expect most doctors to avoid Phentermine as an option for older people that are trying to manage their obesity.

Is Phentermine generally used in short or long-term treatments?

Based on what’s known about Phentermine, the drug is seen as a short-term solution. Although the exact administration timeframe can vary with each patient, it isn’t very common to use Phentermine consistently for the long term.

The drug is used in the short term alongside many other aspects of a weight loss plan. It can help support the effects of diet change, exercise, and other treatments associated with managing obesity.

Can diabetics take Phentermine?

Although diabetics can take Phentermine, doses of insulin may need to be decreased for the time being. It’s important for diabetics to discuss their options with their doctor, as blending medications can cause adverse effects on the health that work against the interest of the patient.

For some, this is easy to manage, but for others, it could pose a challenge that’s hard to overcome. Nevertheless, doctors are well aware of how to navigate this space, and diabetics should have no issue taking Phentermine. This is especially true considering it’s intended for short-term use.

Is the drug habit forming?

Most people won’t have any issue with this, but Phentermine does have the possibility to be habit-forming. Some people are more susceptible to such challenges, but working closely with a doctor will ensure that a habitual attitude doesn’t come to light.

The short-term use of Phentermine can be helpful here, but this isn’t to say that the drug hasn’t been challenging to manage for some people. This shouldn’t pose as much of a concern for patients, but it’s something that should be discussed with your doctor beforehand.

Can I drink alcohol while taking Phentermine?

This isn’t something you should discern on your own, even if some alcohol is allowed while taking Phentermine. If you wish to still drink while treating your obesity, there’s a good chance your doctor will tell you what is and is not allowed.

However, it should be noted that drinking alcohol while taking the drug can potentially exacerbate the prevalence of side effects. Not only that, but it can make the effects of these health concerns much stronger.

Does the drug induce feelings of depression?

In the event of an overdose that isn’t fatal, studies have shown that Phentermine can cause depression, alongside other symptoms. An acute overdose of Phentermine has been shown to give rise to tremors, restlessness, rapid respiration, and many other uncomfortable symptoms.

Depression is something that’s also manageable, but if you end up overdosing on Phentermine, this won’t be the primary concern for your doctors. Feelings of depression aren’t common when taking the drug, but it is possible if administration instructions aren’t followed carefully.